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  • Title: Basal and stimulated calcitonin secretion in primary hyperparathyroidism before and after parathyroidectomy.
    Author: Tabolli S, Valtorta C, Bigi F, Minisola S, Mazzuoli GF.
    Journal: Horm Res; 1986; 23(3):142-6. PubMed ID: 3949287.
    Abstract:
    To investigate calcitonin secretion in primary hyperparathyroidism, basal and stimulated (3 mg Ca++/kg body weight/10 min) immunoreactive calcitonin plasma levels were studied before parathyroidectomy. Plasma calcitonin levels were raised in 50% of patients regardless of sex, but a significant correlation between basal plasma calcium and calcitonin was found only in males. A reduced calcitonin response to calcium infusion was observed in all patients. Parathyroidectomy invariably induced a normalization of calcitonin basal levels. Our findings confirm the existence of a decreased parafollicular cell reserve probably as a consequence of the persistent hypercalcemic state in hyperparathyroid patients and suggest that it is more frequent in females.
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