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  • Title: Increased erythrocyte adenosine deaminase activity without haemolytic anaemia.
    Author: Novelli G, Stocchi V, Giannotti A, Magnani M, Dallapiccola B.
    Journal: Hum Hered; 1986; 36(1):37-40. PubMed ID: 3949358.
    Abstract:
    A 4-fold increase of red blood cell adenosine deaminase (ADA) activity was found in a patient without haemolytic anaemia, but with mild anisopoikilocytosis. High-performance liquid chromatography showed a 40% reduction of adenosine-5'-triphosphate (ATP) while all the other nucleotides were in normal ranges. The patient's parents (first cousins) and a brother displayed the same enzyme activities as the controls. This observation suggests that mild increases of ADA activity is neither a marker for congenital hypoplastic anaemia as previously reported nor associated with haemolytic anaemia.
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