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  • Title: Full-color peptide-based fluorescent nanomaterials assembled under the control of amino acid doping.
    Author: Shen Y, Sun Y, Liang Y, Xu X, Su R, Wang Y, Qi W.
    Journal: Nanoscale Horiz; 2024 Nov 05; ():. PubMed ID: 39498619.
    Abstract:
    Peptide-based biofluorescents are of great interest due to their controllability and biocompatibility, as well as their potential applications in biomedical imaging and biosensing. Here, we present a simple approach to synthesizing full-color fluorescent nanomaterials with broad-spectrum fluorescence emissions, high optical stability, and long fluorescence lifetimes. By doping amino acids during the enzyme-catalyzed oxidative self-assembly of tyrosine-based peptides, we can precisely control the intermolecular interactions to obtain nanoparticles with fluorescence emission at different wavelengths. The synthesized peptide-based fluorescent nanomaterials with excellent biocompatibility and stable near-infrared fluorescence emission were shown to have potential for bioimaging applications. This research provides new ideas for the development of new bioluminescent materials that are cost-effective, environmentally friendly, and safe for biomedical use.
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