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  • Title: Development of a closed-loop artificial pancreas.
    Author: Kraegen EW, Whiteside R, Bell D, Chia YO, Lazarus L.
    Journal: Horm Metab Res Suppl; 1979; (8):38-42. PubMed ID: 395087.
    Abstract:
    A closed-loop glucose controlled insulin infusion system was developed, consisting of elements for continuous blood glucose analysis, a computer control system, and infusion systems. Improvements include decreased size, cost reduction and better performance. The algorithm used was a piecewise linear representation of the sigmoidal curve commonly employed. The apparatus has been applied to simulation of the healthy beta cell and glucose clamp studies.
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