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  • Title: Lysolecithin-induced Ca2+ uptake by pigeon red cells.
    Author: Lee JW, Ting A, Vidaver GA.
    Journal: Life Sci; 1986 Mar 17; 38(11):1013-9. PubMed ID: 3951321.
    Abstract:
    Lysolecithin (LPC) induced a rapid but transitory increase in 45Ca2+ influx, and an abrupt 45Ca2+ net uptake by pigeon red cells. The effect on uptake was seen with doses of added lysolecithin calculated to be 2.1-8.4% of the cytoplasmic membrane phospholipid, well within the reported physiological range of 1-9%. Lysolecithin effects were not due to prelytic membrane changes nor action as a platelet activating factor agonist. Changes in the amino acids in the medium mimicking human homocysteinuria, an atherosclerosis risk factor, increased the lysolecithin effect. The findings are consistent with a role for lysolecithin in atherosclerosis.
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