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  • Title: Impact of Optimal Procedural Result After Transcatheter Edge-to-Edge Tricuspid Valve Repair: Results From TRI-SPA Registry.
    Author: Echarte-Morales J, Guerreiro CE, Freixa X, Arzamendi D, Moñivas V, Carrasco-Chinchilla F, Pan M, Nombela-Franco L, Pascual I, Benito-González T, Perez R, Gómez-Blázquez I, Amat-Santos IJ, Cruz-González I, Sánchez-Recalde Á, Cid Alvarez AB, Barreiro-Perez M, Sanchis L, Caneiro-Queija B, Hion Li C, Del Trigo M, Martínez-Carmona JD, Mesa D, Jiménez P, Avanzas P, Cepas-Guillén P, Estévez-Loureiro R.
    Journal: JACC Cardiovasc Interv; 2024 Dec 09; 17(23):2764-2777. PubMed ID: 39520435.
    Abstract:
    BACKGROUND: Procedural success following tricuspid transcatheter edge-to-edge repair (TEER) has been defined variably over time; however, the consequences of achieving a tricuspid regurgitation (TR) grade of 0/1+ are still unclear. OBJECTIVES: This study aimed to assess the predictors and prognostic impact of achieving TR 0/1+ after TEER and its role in clinical events. METHODS: This multicenter registry included patients undergoing tricuspid TEER in 15 Spanish centers from June 2020 and May 2023. Patients were categorized into the following groups based on the TR grade after procedure: optimal (0/1+), acceptable (2+), and not acceptable (≥3+). The primary endpoint was the 1-year composite of all-cause death, heart failure hospitalization, and tricuspid reintervention. Secondary endpoints included each component of the primary endpoint assessed separately, NYHA functional class, and TR grade at follow-up. RESULTS: Among 280 enrolled patients, 120 (42.9%) had residual TR 0/1+, 111 (39.6%) had residual TR 2+, and 49 (17.5%) had residual TR ≥3+. Patients with TR 0/1+ experienced lower rates of the primary endpoint (13% vs 20% vs 31%; log-rank P = 0.036). Residual TR ≥3+ was an independent predictor of primary endpoint (HR: 2.277; P = 0.044). Higher rates of NYHA functional class I or II and sustained TR reduction were seen in the TR 0/1+ group (P < 0.001 for both). A small coaptation gap and absence of septal leaflet tethering were independent predictors of achieving TR 0/1+. CONCLUSIONS: An optimal procedural result after TEER might be associated with improved outcomes. TR coaptation gap and leaflet restriction may aid in assessing suitability for TEER.
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