These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: First trimester diagnosis of beta-thalassaemia in a twin pregnancy.
    Author: Monni G, Rosatelli C, Falchi AM, Scalas MT, Addis M, Maccioni L, di Tucci A, Tuveri T, Cao A.
    Journal: Prenat Diagn; 1986; 6(1):63-8. PubMed ID: 3952059.
    Abstract:
    This paper reports the results of first trimester prenatal diagnosis in a twin pregnancy at risk for homozygous beta 0-thalassaemia (beta 0-39 mutant). Trophoblast samples from both twins were obtained at 10 weeks gestation with a forceps guided by ultrasound. Trophoblast DNA analysis, carried out with the oligonucleotide technique, revealed that one fetus was homozygous and the other heterozygous for the beta-39 mutant. This diagnosis was confirmed at 17 weeks gestation by amniocyte DNA analysis. DNA polymorphism analysis within the alpha-globin gene provided useful genetic markers for twin differentiation.
    [Abstract] [Full Text] [Related] [New Search]