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  • Title: [Cyclic nucleotides and lipids in the realization of the radioprotective effect of ceruloplasmin].
    Author: Antonenko SG, Sanina OL, Chebotarev EE.
    Journal: Radiobiologiia; 1986; 26(1):112-5. PubMed ID: 3952276.
    Abstract:
    Ceruloplasmin administered 60 min before irradiation diminished cAMP and cGMP levels, which were increased by irradiation at LD50 and LD100, and normalized cAMP/cGMP ratio in the rat liver during the first 24 h following irradiation with a dose of 6.24 Gy. The content of phospholipids increased and that of cholesterol decreased under the effect of ceruloplasmin leading to normalization of the molar cholesterol/phospholipid ratio in the rat liver on the 7th day of radiation sickness (LD50, 6.24 Gy).
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