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  • Title: Streptococcal endocarditis: single vs. combination antibiotic therapy and role of various species.
    Author: Tuazon CU, Gill V, Gill F.
    Journal: Rev Infect Dis; 1986; 8(1):54-60. PubMed ID: 3952425.
    Abstract:
    Forty-eight patients with 51 episodes of infective endocarditis caused by streptococci were studied in a comparison of the efficacy of single antibiotic therapy versus that of combination therapy. There was no statistical difference in terms of clinical course, toxicity, and mortality between the group given a single drug and that given combination therapy. However, one patient experienced two relapses, in both instances after high-dose penicillin therapy. The species and antibiotic susceptibilities of the infecting organisms were determined. The majority of isolates were alpha-hemolytic, with Streptococcus sanguis recovered most commonly. Streptococcus bovis and group B beta-hemolytic streptococci were the next most frequent isolates.
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