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  • Title: [The regulation of bone remodeling].
    Author: Trechsel U.
    Journal: Schweiz Med Wochenschr; 1986 Feb 08; 116(6):179-82. PubMed ID: 3952473.
    Abstract:
    The adult skeleton is subject to a remodeling process which must be tightly regulated to keep bone mass constant. Bone resorption and bone formation are coupled. After a brief review of the cellular mechanisms of bone remodeling, its regulation is discussed. Bone resorption is modulated by parathyroid hormone, 1,25-dihydroxyvitamin D and other hormones. Locally, agents such as prostaglandins and factors from the immune system are important. Bone formation is stimulated by insulin and somatomedin C (= insulin like growth factor 1) which mediates the effect of growth hormone. Other hormones and local factors also play a role.
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