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  • Title: Antihypertensive effects of intra-cisternal beta-blocking agents in dogs with acute nerogenic hypertension.
    Author: Montastruc JL, Montastruc P.
    Journal: Arch Int Pharmacodyn Ther; 1979 Feb; 237(2):275-81. PubMed ID: 39526.
    Abstract:
    Dl-propranolol, acebutolol, atenolol, bupranolol, oxprenolol, pindolol, practolol, sotalol and d-propranolol were injected into the cisterna magna of anesthetized dogs with neurogenic hypertension induced by deafferentation and vagotomy. Dl-propranolol and bupranolol correct the hypertension and the tachycardia of the debuffered dog, whereas oxprenolol has only an action on the heart rate. The other beta-blocking drugs and d-propranolol were inactive at the doses used. Our results show that a mere central effect cannot explain the antihypertensive properties of all the tested beta-blocking agents.
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