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  • Title: [Changes in the lipid levels of the liver, plasma, aorta and cholesterol esterase activity of the rat liver during exposure to tetrachloromethane].
    Author: Dolgov AV, Dushkin MI, Morozov AV, Morozova IIu.
    Journal: Vopr Med Khim; 1986; 32(1):55-8. PubMed ID: 3953013.
    Abstract:
    Content of cholesterol esters was increased 2.3-fold, triglycerides--4.7-fold, phospholipids--1.5-fold in liver tissue of CCl4-treated rats. The increase in the content of cholesterol esters and triglycerides correlated with a decrease in activity of lysosomal cholesterol esterase from liver tissue. After CCl4 intoxication content of free cholesterol was decreased 2.1-fold, free fatty acids--2-fold, phospholipids--2.3-fold, triglycerides--1.75-fold in blood. In aorta an increase in content of cholesterol esters and triglycerides was found to be 2-fold as well as activation of the cytosolic cholesterol esterase was noted. The data obtained suggest that intoxication with CCl4 affected the accumulation of cholesterol esters in the arterial wall.
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