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  • Title: Correlation of methacholine-induced non-specific bronchial reactivity and cold air hyperventilation challenge.
    Author: Nair N, Hopp RJ, Alper BI, Bewtra AK, Townley RG.
    Journal: Ann Allergy; 1986 Mar; 56(3):226-8. PubMed ID: 3954163.
    Abstract:
    The degree of bronchoconstriction seen with cold air hyperventilation challenge was determined in 48 adult subjects with known degrees of methacholine-induced bronchial reactivity. The degree of bronchial reactivity as determined by the cold air hyperventilation challenge significantly correlated with the non-specific bronchial reactivity determined by a methacholine inhalation challenge. Cold air hyperventilation challenge can accurately confirm the presence of reactive airway disease.
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