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  • Title: Trans-stimulation and trans-inhibition of uridine efflux from human erythrocytes by permeant nucleosides.
    Author: Jarvis SM.
    Journal: Biochem J; 1986 Jan 01; 233(1):295-7. PubMed ID: 3954730.
    Abstract:
    The ability of nucleoside permeants to accelerate the efflux of uridine from human erythrocytes has been compared. In contrast to uridine, 2-chloroadenosine acted as a trans-inhibitor of uridine efflux from fresh human erythrocytes, and adenosine had little effect. These results are consistent with the lower maximum velocity for influx of 2-chloroadenosine and adenosine as compared with uridine and demonstrate that trans acceleration experiments do not discriminate between transported and non-transported permeants for the human erythrocyte nucleoside carrier.
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