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  • Title: Occurrence of elevated protoporphyrin levels in relation to lead burden in infants.
    Author: Rabinowitz MB, Leviton A, Needleman HL.
    Journal: Environ Res; 1986 Apr; 39(2):253-7. PubMed ID: 3956457.
    Abstract:
    Simultaneous blood lead (PbB), erythrocyte protoporphyrin (EP), and hematocrit measurements were made semiannually in 232 normal infants from 6 to 24 months of age. The PbB averaged 7 (SD = 5) and ranged from 0 to 64 micrograms/dl. The incidence of elevated EP, a marker for deranged heme synthesis, was unrelated to PbB at levels below 15 micrograms/dl but was fourfold greater among the infants with PbB above 15 micrograms/dl. This relationship persisted even after eliminating the 31 (4%) anemic (hematocrit less than 33%) samples. The confounding effects of iron deficiency are discussed.
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