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  • Title: Derivatives of 1,3,3-trimethyl-6-azabicyclo-[3.2.1]octane with hypotensive activity. III.
    Author: Mariani E, Bondavalli F, Schenone P, Marrazzo R, Russo S, Di Guglielmo R, Marmo E.
    Journal: Farmaco Sci; 1986 Jan; 41(1):49-53. PubMed ID: 3956719.
    Abstract:
    The synthesis of a series of alkyl and aryl thioureas (II) starting from 1,3,3-trimethyl-6-azabicyclo[3.2.1]octane is described. Some of alkyl thioureas showed a moderate hypotensive activity in rats. Effects on heart rate and hypoglycemic activity in rats, infiltration anesthesia and antiarrhythmic activity in mice are also reported.
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