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  • Title: Nuclear deoxyribonucleic acid heterogeneity of ovarian borderline malignant serous tumors.
    Author: Fu YS, Ro J, Reagan JW, Hall TL, Berek J.
    Journal: Obstet Gynecol; 1986 Apr; 67(4):478-82. PubMed ID: 3960418.
    Abstract:
    Sixteen borderline malignant serous ovarian tumors and seven well-differentiated invasive serous ovarian carcinomas were examined with the technique of Feulgen microspectrophotometry for the determination of nuclear deoxyribonucleic acid (DNA) ploidy patterns (diploid versus aneuploid) and ploidy levels of the stem cell lines. Of the nine stage I-II borderline malignant tumors, only one (11%) was aneuploid. In contrast, four of seven (57%) stage III borderline malignant neoplasms and all stage III carcinomas were aneuploid. The stem cell modal values in all borderline serous tumors were less than triploid (3N) while in five of seven carcinomas stem cell modal values were greater than triploidy. This contrast in ploidy patterns and ploidy levels may explain the differences in biologic behavior between borderline malignant serous tumors and invasive serous carcinomas of the ovary.
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