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  • Title: A comparative study of theophylline in a slow-release 'sprinkle' format with a standard syrup preparation in young children with asthma.
    Author: Dawson KP.
    Journal: Pharmatherapeutica; 1986; 4(7):442-4. PubMed ID: 3960944.
    Abstract:
    Sixty-one chronic asthmatic children received either a new slow-release sprinkle format of theophylline, twice daily, or theophylline liquid, 4-times per day. Over a study period of three months, there was no measurable difference in compliance or symptom control between the two groups. The sprinkle-treated patients, however, had a greater incidence of side-effects and had higher rates of nebulization with beta-agonists. Possible explanations are discussed.
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