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  • Title: [The spectrum of fatty acids in blood lipids and lymph of the small intestine in dogs with hypercholesterolemia].
    Author: Kosukhin AB, Nikitin BN, Syzdykova RT.
    Journal: Vopr Pitan; 1986; (1):59-63. PubMed ID: 3962271.
    Abstract:
    Experimental alimentary hypercholesterolemia in conditions of thyroid blocking was attended by accumulation of esterified fatty acids (EFA) in the atherogenic lipoproteins of the blood plasma and lymph in the intestine. Rearrangement of EFA pool depended to a great measure on the reduction of linoleate share in cholesterol phospholipids and ethers. The concentration of free linoleate decreased. Arteriovenous difference in the content of free linoleate was detected only in intact animals. It is supposed that changed parameters of penetration of free linoleate into enterocytes are related to enhanced endocytosis of the blood plasma lipoproteins and to intracellular accumulation of fatty acids, that may be responsible for similarity of EFA composition in hypercholesterolemia. As a result, a part of free linoleate pool, normally engaged in lipid synthesis, is spent for energy purposes. This may predetermine a relative depletion of blood plasma lipoprotein linoleate in hypercholesterolemia.
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