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  • Title: [Equivalence of oral and intramuscular premedication. II. Effect of various conventional premedication drugs].
    Author: Grabow L, Hein A, Hendrikx B, Thiel W, Schilling E.
    Journal: Anasth Intensivther Notfallmed; 1986 Feb; 21(1):17-9. PubMed ID: 3963319.
    Abstract:
    In a randomised study, 6 different premedications (oral flunitrazepam, oral pentobarbital, oral physiological NaCl solution, intramuscular pethidine, intramuscular droperidol/fentanyl, intramuscular physiological NaCl solution) were administered to 600 patients to determine the equal efficacy of the premedicative drugs in oral or parenteral administration. Patients gave the best rating to the oral application of flunitrazepam. The differences in the assessment of application and effect of the drugs are contrasted by the statement that most patients do not feel any direct influence on their preoperative anxiety by premedication. However, it is easier for them to cope with anxiety because premedication pacifies the patients, whereas each of the dependent variables, such as apprehension, is influenced differently. Oral premedication again proves superior to parenteral premedication.
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