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  • Title: Familial nonspherocytic hemolytic anemia in poodles.
    Author: Randolph JF, Center SA, Kallfelz FA, Blue JT, Dodds WJ, Harvey JW, Paglia DE, Walsh KM, Shelly SM.
    Journal: Am J Vet Res; 1986 Mar; 47(3):687-95. PubMed ID: 3963571.
    Abstract:
    Nonspherocytic hemolytic anemia, characterized by marked reticulocytosis, hepatosplenomegaly, hemosiderosis of reticuloendothelial organs and bone marrow myelofibrosis, and osteosclerosis, was diagnosed in 5 related Poodles. The unremitting anemia was clinically evident by 1 year of age, and was fatal as early as 3 years of age. Despite intense diagnostic endeavors including RBC fragility studies, RBC enzyme assays, and hemoglobin electrophoresis, the cause of this nonspherocytic hemolytic anemia remains to be determined.
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