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  • Title: [Immunomodulation by antitumor antibiotics].
    Author: Ishizuka M.
    Journal: Gan To Kagaku Ryoho; 1986 Mar; 13(3 Pt 2):697-700. PubMed ID: 3963840.
    Abstract:
    Antibiotics exhibiting immunomodulatory activities were found among antitumor antibiotics. These antibiotics had antileukemic activity. Neothramycin and mazethramycin, which are classified as anthramycin-group antibiotics, activated macrophages so that they became antitumor effector cells. Aclacinomycin and oxanosine inhibited generation of suppressor cells in tumor-bearing mice and oxanosine enhanced antitumor effector cells. Therapy using spergualin produced specific antitumor immunity in cured mice. The immunomodulatory activities of auromomycin and bactobolin were also reported.
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