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Title: Labile oligomeric structure of human placental 15-hydroxyprostaglandin dehydrogenase. Author: Tanaka T, Kotani T, Ohtaki S, Nagai K, Tsuruta K, Mori N. Journal: Biochem Biophys Res Commun; 1986 Mar 28; 135(3):1058-63. PubMed ID: 3964268. Abstract: NAD-dependent 15-hydroxyprostaglandin dehydrogenase has been isolated from human term placenta. About 9,000-fold enrichment was achieved with a yield of 7.6%. Electrophoretic analyses suggested that glycerol stabilized an active structure of the enzyme, and sodium dodecyl sulfate might dissociate it. The instability of the enzyme activity may relate to its labile oligomeric structure which is easily dissociated into subunits.[Abstract] [Full Text] [Related] [New Search]