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  • Title: [Gastroduodenal tolerability of indomethacin and acetaminophen. A comparative endoscopic study in healthy subjects].
    Author: Müller P, Dammann HG, Simon B.
    Journal: Arzneimittelforschung; 1986 Feb; 36(2):269-70. PubMed ID: 3964334.
    Abstract:
    The effect of a 5- and 10-day treatment with indometacin and acemetacin (Rantudil) on the gastroduodenal mucosa was endoscopically evaluated in 16 healthy volunteers. In a randomised double-blind cross-over fashion the volunteers received 50 mg t.i.d. indometacin as well as 60 mg t.i.d. acemetacin. Acemetacin evoked after 5 and 10 days significantly less gastroduodenal lesions than indometacin. Possible reasons for this apparently better tolerability of acemetacin in man are discussed.
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