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  • Title: The prediction of anatomical morphology of primary aldosteronism using serum 18-hydroxycorticosterone levels.
    Author: Kem DC, Tang K, Hanson CS, Brown RD, Painton R, Weinberger MH, Hollifield JW.
    Journal: J Clin Endocrinol Metab; 1985 Jan; 60(1):67-73. PubMed ID: 3964794.
    Abstract:
    Serum 18-hydroxycorticosterone, aldosterone, and potassium were measured under basal conditions in 34 patients with documented primary aldosteronism, 10 patients with essential hypertension, and 9 normal subjects. The results revealed that 22 of 23 patients with aldosterone-producing adenomas had 18-hydroxycorticosterone levels greater than 100 ng/dl, and all 9 patients with idiopathic adrenal hyperplasia had plasma levels less than 100 ng/dl. Two patients with unusual macromicronodular hyperplasia of the adrenal glands had levels greater than 100 ng/dl. We found a significant relationship between serum potassium and the ratio of 18-hydroxycorticosterone to aldosterone in patients with idiopathic adrenal hyperplasia, but not in those with an aldosterone-producing adenoma. We conclude that measurement of serum 18-hydroxycorticosterone is a useful predictor of the etiology of primary aldosteronism.
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