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  • Title: Bile acid metabolism during development: metabolism of taurodeoxycholic acid in human fetal liver.
    Author: Gustafsson J, Andersson S, Sjövall J.
    Journal: Biol Neonate; 1985; 47(1):26-31. PubMed ID: 3967055.
    Abstract:
    The metabolism of tauro-[24-14C]deoxycholic acid was studied in microsomal preparations from fetal liver. The livers were obtained at legal abortions performed between week 13 and 24. Taurodeoxycholic acid was efficiently hydroxylated in the 1 beta- and 7 alpha-positions. The hydroxylase activities did not increase with gestational age. A marked variation in extent of hydroxylation was noted between different preparations. The results are discussed in relation to earlier knowledge of fetal and neonatal bile acid metabolism.
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