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  • Title: Vancomycin prevents polytetrafluoroethylene graft infections in pediatric patients receiving chronic hemodialysis.
    Author: Fivush BA, Bock GH, Guzzetta PC, Salcedo JR, Ruley EJ.
    Journal: Am J Kidney Dis; 1985 Feb; 5(2):120-3. PubMed ID: 3970016.
    Abstract:
    Polytetrafluoroethylene (PTFE) grafts have been a useful addition to the pediatric hemodialysis vascular access armamentarium. In this study, 17 pediatric patients underwent 331 total months of hemodialysis via PTFE grafts. There was a statistically significant (P less than .025) decrease in the incidence of graft infections in 12 patients (235 patient-months) while receiving prophylactic parenteral vancomycin compared with 9 patients (96 patient-months) while receiving no vancomycin (0% v 44%). Vancomycin side effects were uncommon and mild. Vancomycin is a safe and effective agent for the prevention of PTFE graft infections in pediatric patients receiving chronic hemodialysis.
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