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  • Title: Soluble antigens released in vitro from erythrocytes infected with Plasmodium berghei.
    Author: Weissberger H, Golenser J, Spira DT.
    Journal: Bull World Health Organ; 1979; 57 Suppl 1(Suppl):83. PubMed ID: 397011.
    Abstract:
    Rat erythrocytes parasitized with Plasmodium berghei were found to release soluble antigenic products in vitro. The supernatants obtained by centrifugation of the disrupted cells induced specific transformation of non-adherent spleen lymphocytes of convalescent rats and produced precipitation lines with antiplasmodial antibodies. In a preliminary experiment they also immunized young rats against a viable challenge of P. berghei. It is suggested that the soluble material could serve for the purification of an effective protective antigen.
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