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  • Title: Alternative-substrate inhibition of L-lactate transport via the monocarboxylate-specific carrier system in human erythrocytes.
    Author: de Bruijne AW, Vreeburg H, van Steveninck J.
    Journal: Biochim Biophys Acta; 1985 Feb 14; 812(3):841-4. PubMed ID: 3970911.
    Abstract:
    The L-lactate/proton symport system of the red blood cell membrane was studied under conditions of alternative-substrate inhibition by glycolate. At constant pH of the medium glycolate caused competitive inhibition of L-lactate transport. In Lineweaver-Burk plots of 1/v against 1/[H], on the other hand, glycolate caused an uncompetitive inhibition. These observations indicate, that the monocarboxylate carrier exhibits ordered substrate binding, with the proton binding first.
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