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  • Title: Significant potassium ion accumulation at the external surface of Myxicola giant axons.
    Author: Moran N, Levitan E, Palti Y, Roslansky P, Adelman WJ.
    Journal: Biochim Biophys Acta; 1985 Mar 14; 813(2):213-20. PubMed ID: 3970922.
    Abstract:
    Potassium accumulation associated with outward membrane potassium current was investigated experimentally in Myxicola giant axon. During prolonged voltage-clamp pulses to positive transmembrane potentials, the K+ equilibrium potential may approach zero mV, suggesting massive K+ accumulation outside the axonal membrane to concentrations many-fold higher than those in the bathing medium. The potassium accumulation can be satisfactorily described by a three-compartment model, consisting of the nerve fiber, a restricted physiological periaxonal space and the bulk solution. The average thickness, theta, of the periaxonal space is calculated as 177 +/- 59 A, i.e., comparable to that in the squid, while the permeability coefficient of the external barrier, PKs, was calculated to be (1.4 +/- 0.4) X 10(-4) cm/s. These conclusions are well supported by morphological study.
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