These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Properties of macrophages from low- and high-responder strains of mice. I. Effect of antigenic stimulation.
    Author: Vĕtvicka V, Fornůsek L, Ríhová B, Kopecek J.
    Journal: Folia Biol (Praha); 1985; 31(1):20-33. PubMed ID: 3972142.
    Abstract:
    In the high-responder A/J mice a lower percentage of peritoneal macrophages express Fc receptors and accordingly phagocytize less intensely via these receptors than the macrophages of the low-IgG-responder C57BL/10ScSn strain. Similarly, the phagocytosis mediated by the receptors for foreign substances tested by CdCO3 microcrystals is lower in the A/J strain. Pinocytic activity was the same in both mouse strains. Intraperitoneal immunization with sheep red blood cells led to a prompt increase in Fc receptor expression and in both phagocytic and pinocytic activities in A/J mice, while in C57BL/10ScSn mice these activities remained unchanged. A similar effect was found when spontaneous and induced rosette formation with sheep red blood cells was studied. The opposite was true when the phagocytic activity of peripheral leucocytes to non-antigenic synthetic microspheres was studied; after immunization with sheep red blood cells a strong increase was observed not in the A/J but C57BL/10ScSn strain. The importance of these results for the regulatory role of macrophages in immune responses in the low- and high-IgG-responder strains of mice is discussed.
    [Abstract] [Full Text] [Related] [New Search]