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  • Title: Failure of serology in diagnosing chlamydial infections of the female genital tract.
    Author: Schachter J, Cles L, Ray R, Hines PA.
    Journal: J Clin Microbiol; 1979 Nov; 10(5):647-9. PubMed ID: 397220.
    Abstract:
    Chlamydia trachomatis was recoved from 20% (36/180) of women attending a venereal disease clinic. All infected women had chlamydial antibodies in their serum and cervical secretions. However, the background rates of chlamydial antibody in chlamydia-negative women were very high. Measurement of antibodies in serum (complement fixation or immunoglobulin G [IgG] and IgM by microimmunofluorescence) or cervical secretion (IgG, IgM, IgA or secretory IgA classes) did not result in predictive values of greater than 32%. It is concluded that the detection of chlamydial antibodies in serum or cervical secretions cannot be substituted for agent isolation in diagnosing these infections.
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