These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: The metabolism of 14C-methoxsalen by the dog.
    Author: Kolis SJ, Williams TH, Postma EJ, Sasso GJ, Confalone PN, Schwartz MA.
    Journal: Drug Metab Dispos; 1979; 7(4):220-5. PubMed ID: 39724.
    Abstract:
    Single doses of 14C-methoxsalen (5 mg/kg) were administered iv to three dogs. Almost as much administered radioactivity was excreted in the feces as in the urine, suggesting that biliary secretion of metabolites was an important route of excretion. 14C-Methoxsalen disappeared rapidly from plasma, although plasma levels of radioactivity persisted for 5 weeks after drug administration. Evidence was obtained which suggested that the persistent plasma radioactivity was due to a metabolite bound to plasma protein. Four urinary metabolites were isolated. Three of the metabolites resulted from opening of the furan ring; these are 7-hydroxy-8-methoxy-2-oxo-2H-1-benzopyran-6-acetic acid (A), alpha,7-dihydroxy-8-methoxy-2-oxo-2H-1-benzopyran-6-acetic acid (B), and an unknown conjugate of A at the 7-hydroxy position. The fourth metabolite, formed by opening of the pyrone ring, is an unknown conjugate of (Z)-3-(6-hydroxy-7-methoxybenzofuran-5-yl)-2-propenoic acid.
    [Abstract] [Full Text] [Related] [New Search]