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  • Title: Hexitol production by canine retinal microvessels.
    Author: Kern TS, Engerman RL.
    Journal: Invest Ophthalmol Vis Sci; 1985 Mar; 26(3):382-4. PubMed ID: 3972519.
    Abstract:
    Hexitol-producing activity has been quantitated in microvessels isolated from retina and cerebral cortex of dogs, a species known to develop a retinopathy similar to that seen in diabetic patients. Both the retinal and cerebral microvessels produce galactitol from galactose, but at a rate several-fold less than that seen in canine lens epithelium. This hexitol-producing activity of the microvessels is not an artifact of erythrocyte contamination and can be inhibited by the aldose reductase inhibitor, Sorbinil.
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