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  • Title: The stabilization of vancomycin by peptidoglycan analogs.
    Author: Harris CM, Kopecka H, Harris TM.
    Journal: J Antibiot (Tokyo); 1985 Jan; 38(1):51-7. PubMed ID: 3972728.
    Abstract:
    The glycopeptide antibiotic vancomycin is unstable in solution. It undergoes a rearrangement involving the conversion of an asparagine residue to isoaspartate to give an antibiotically inactive species, CDP-I. Peptide analogs of bacterial peptidoglycan, such as Ac-D-Ala-D-Ala and di-Ac-L-Lys-D-Ala-D-Ala bind to vancomycin and stabilize the antibiotic against degradation and consequent loss of activity. Protection by peptide is effective even under prolonged heating at 80 degrees C or steam sterilization (30 minutes, 10(4) kg/m2).
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