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  • Title: Insulin binding to human ovaries.
    Author: Jarrett JC, Ballejo G, Tsibris JC, Spellacy WN.
    Journal: J Clin Endocrinol Metab; 1985 Mar; 60(3):460-3. PubMed ID: 3972961.
    Abstract:
    Human ovarian tissue samples were obtained at the time of laparotomy, and plasma membrane fractions were prepared and used in receptor assays. Incubations of the membrane fraction were performed with [125I]insulin (porcine), and Scatchard analysis of binding showed biphasic curves. The high affinity sites had an average concentration of 57.4 +/- 7.9 (+/- SEM) fmol/mg protein and a dissociation constant of 3.5 +/- 0.9 nM (n = 9). Neither affinity nor number of binding sites changed significantly during the menstrual cycle. We conclude that there is high affinity binding of [125I]insulin to human ovarian plasma membranes.
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