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  • Title: Vitamin C intoxication and hyperoxalemia in chronic hemodialysis patients.
    Author: Pru C, Eaton J, Kjellstrand C.
    Journal: Nephron; 1985; 39(2):112-6. PubMed ID: 3974772.
    Abstract:
    We studied vitamin C levels in 25 stable patients on chronic hemodialysis who were taking 0.5-1 g vitamin C orally daily and/or dialyzed against dialysate containing 33.3 micrograms/ml of vitamin C. We also studied the relationship between serum vitamin C and oxalate levels in 7 patients on chronic hemodialysis. All patients had markedly elevated pre- and postdialysis levels of vitamin C. The predialysis levels of vitamin C showed extremely good correlation to the serum oxalate levels. Overingestion of vitamin C in food or as supplementation may lead to excessive serum levels of vitamin C, resulting in hyperoxalemia that may contribute to vascular disease in patients on chronic hemodialysis.
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