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  • Title: Alkylation of bronchiolar epithelial cells by 3-methylindole metabolites in the horse.
    Author: Becker GM, Nocerini MR, Carlson JR, Breeze RG.
    Journal: Toxicol Lett; 1985 Jan; 24(1):25-32. PubMed ID: 3975927.
    Abstract:
    Autoradiographs of horse-lung explants incubated with [3H]3-methylindole (3MI) showed 8 times greater labeling per area to bronchiolar epithelial cells than to the interalveolar septa. Incubations of horse-lung microsomes with [14C]3MI resulted in alkylation of microsomal proteins, which could be reduced by exogenous glutathione. An apparent covalent adduct of glutathione and 3MI was isolated from these incubations. These results suggest that the target cells of 3MI-induced injury in the horse, the bronchiolar epithelial cells, are alkylated by an electrophilic 3MI intermediate.
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