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  • Title: [Correction of lipid peroxidation disorders in experimental traumatic shock using the antioxidant ionol].
    Author: Iakubenko ED, Mareeva TE, Manankov AK.
    Journal: Ukr Biokhim Zh (1978); 1985; 57(1):79-82. PubMed ID: 3976019.
    Abstract:
    The level of certain parameters of lipid peroxidation and the activity of lysosome hydrolases were studied on the shock model in rats. It was established that the traumatic shock in the experiment is accompanied by the growth of the level of over-oxidation products (malonic dialdehyde, diene conjugates), the rate of erythrocyte hemolysis as well as by an increase in the hydrolase activity. Administration of ionol (60 mg/kg) inhibits the higher activity of radical-free lipid oxidation, decreases the damage of membrane structure and the metabolism disturbance.
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