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  • Title: [Change in the level of steroid hormone receptors in the tumors of patients with breast cancer complicated by liver and bile duct diseases].
    Author: Portnoĭ SM, Smirnova KD, Bassalyk LS, Murav'eva NI, Kuz'mina ZV.
    Journal: Vopr Onkol; 1985; 31(1):55-9. PubMed ID: 3976195.
    Abstract:
    Estrogen, progesterone and glucocorticoid receptor levels were assayed in cytosols of primary tumor in 132 patients with breast cancer. Concomitant diseases of the liver and bile ducts were detected in 13 of them. Patients with concomitant hepatic pathology showed a relatively lower percentage of tumors bearing receptors of the above steroid hormones. This was matched by a significant reduction in the level of progesterone receptors. The frequency of identification of receptors of both estrogens and progesterone in tumor in cases of concomitant hepatic pathology was three times less than in those free from it.
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