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  • Title: Retinoic acid treatment of human neuroblastoma cells is associated with decreased N-myc expression.
    Author: Amatruda TT, Sidell N, Ranyard J, Koeffler HP.
    Journal: Biochem Biophys Res Commun; 1985 Feb 15; 126(3):1189-95. PubMed ID: 3977910.
    Abstract:
    Cells from human neuroectodermal tumors (retinoblastoma and neuroblastoma) and from neuroblastoma cell lines express a gene, N-myc, which is frequently amplified in these tumors. We report here that N-myc mRNA content is markedly decreased in cells of a neuroblastoma cell line (LA-N-5) following differentiation induced with retinoic acid. Exposure of the cells to retinoic acid induced morphologic changes consistent with neuronal differentiation, and led to a 75% decrease in expression of N-myc mRNA. These results suggest that N-myc expression is intimately related to an undifferentiated phenotype in neuroblastoma cells, and support other studies which relate N-myc expression to the malignant phenotype in neuroblastoma tumors.
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