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  • Title: Desensitization of human platelets by platelet activating factor.
    Author: Chesney CM, Pifer DD, Huch KM.
    Journal: Biochem Biophys Res Commun; 1985 Feb 28; 127(1):24-30. PubMed ID: 3977920.
    Abstract:
    Human platelets are less responsive to PAF at 37 degrees than at 25 degrees. They can be desensitized to the effects of PAF by pre-exposure to small concentrations. In both cases desensitization appears to be accompanied by a decreased affinity of the high affinity site for PAF rather than loss of binding sites. Alteration of a metabolic step subsequent to binding cannot be excluded, but platelets show normal response to a variety of other agents under the conditions resulting in desensitization of platelets to PAF.
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