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  • Title: The vasorelaxant action of parathyroid hormone fragments on isolated rat tail artery.
    Author: Pang PK, Yang MC, Shew R, Tenner TE.
    Journal: Blood Vessels; 1985; 22(2):57-64. PubMed ID: 3978237.
    Abstract:
    Previous studies have demonstrated that parathyroid hormone (PTH) and its 1-34 amino terminal fragment possess a hypotensive action in vivo which appeared to be direct and dose-dependent. However, attempts to demonstrate the phenomenon in isolated vascular tissue have been minimally successful at best. The present study reports that bovine PTH-(1-34) can relax isolated rat tail artery helical strips precontracted by either arginine vasopressin, depolarizing concentrations of potassium chloride, or norepinephrine. The phenomenon occurs in a dose-dependent manner and is not dependent upon the presence of the endothelial lining of the vessels. These studies support the hypothesis that bovine PTH-(1-34) produces a direct vasorelaxant action mainly in small arteries.
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