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  • Title: [Synthesis of globin mRNA in cultured murine erythroleukemic cells, transformed by Rauscher leukemia virus].
    Author: Peresleni TIu, Mechetner EB, Rozinova EN, Dvorkin GA.
    Journal: Biokhimiia; 1979 Nov; 44(11):1988-93. PubMed ID: 397837.
    Abstract:
    In contrast to cultured erythroleukemic cells transformed by Friend leukemia virus, in the cultured erythroleukemic murine cells transformed by Rauscher leukemia virus, the synthesis of haemoglobin cannot be induced after treatment with 1--2% dimethylsulfoxide, actinomycin D and proteolytic enzymes. Study of disturbances in the haemoglobin synthesis in this cell culture revealed that globin 9S-mRNA is either absent or present in negligible amounts in the culture. The data obtained suggest that the disturbances in haemoglobin synthesis occur at the level of transcription or processing of globin mRNA, rather than at the level of translation.
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