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  • Title: Conversion of dense lysosomes into light lysosomes during hepatocytic autophagy.
    Author: Seglen PO, Solheim AE.
    Journal: Exp Cell Res; 1985 Apr; 157(2):550-5. PubMed ID: 3979450.
    Abstract:
    Incubation of isolated rat hepatocytes under conditions which support maximal autophagy (amino acid-free medium) caused a marked alteration in the density distribution of lysosomes in continuous metrizamide gradients (mean peak density reduced from 1.14 to 1.09 g/ml). The autophagic sequestration inhibitor 3-methyladenine (3MA) partially prevented the density shift, presumably by stopping the formation of light autophagosomes which otherwise fuse with dense lysosomes and thereby alter the lysosomal density.
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