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  • Title: [Research on the pharmacokinetics of ftorotan and pemtrane in human blood using gas-liquid chromatography].
    Author: Keda BI.
    Journal: Farmakol Toksikol; 1985; 48(1):39-43. PubMed ID: 3979534.
    Abstract:
    Gas liquid chromatography was used to study and compare the changes in pentrane and halothane concentrations in the blood of patients with general surgical diseases under the conditions of monopentrane and combined (pentrane plus nitrous oxide) anesthesia (19 children aged 1-14 years), monohalothane anesthesia with different types of premedication (18 children aged 6-12 years) and with different types of the general anesthesia maintenance (24 patients aged 20-52 years). The use of combined anesthesia and premedication with suppositories containing phentanyl, methacin and etaperazine under the conditions of monohalothane anesthesia makes it possible, upon the attainment of stage III1 anesthesia, to reduce the concentration of the fluorine-containing anesthetics in the venous blood of the children by 1.7-1.8 times on an average. The maintenance of the general anesthesia by subanesthetic concentrations of a mixture of halothane, pentrane, nitrous oxide and phentanyl provides for adequate general anesthesia with substantially reduced concentrations of the fluorine-containing anesthetics in the arterial and venous blood of patients at the main stage of surgical intervention: halothane concentration is reduced 1.6 and 1.7-fold, that of pentrane 2.6- and 3.6-fold, respectively.
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