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  • Title: Aryldiazonium salts as photoaffinity labels of the nicotinic acetylcholine receptor PCP binding site.
    Author: Kotzyba-Hibert F, Lagenbuch-Cachat J, Jaganathen J, Goeldner M, Hirth C.
    Journal: FEBS Lett; 1985 Mar 25; 182(2):297-301. PubMed ID: 3979552.
    Abstract:
    Several aryldiazonium salts are described as irreversible blockers of the phencyclidine binding site of the nicotinic cholinergic receptor. A partial hydrophobic character increases the affinity of these salts for the phencyclidine binding site. Photoaffinity labelling with a tritiated diazonium salt in the presence of either carbamylcholine or alpha-bungarotoxin leads to incorporation of radioactivity into the 4 subunits of the receptor. Among these diazonium salts, an imidazole derivative is unique in that the photoinduced irreversible blocking in only effective when the receptor is in a desensitised state.
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