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  • Title: Sequence-specific chemical modification of a 365-nucleotide-long DNA fragment with an alkylating oligonucleotide derivative.
    Author: Vlassov VV, Gaidamakov SA, Gorn VV, Grachev SA.
    Journal: FEBS Lett; 1985 Mar 25; 182(2):415-8. PubMed ID: 3979561.
    Abstract:
    An aromatic 2-chloroethylamino group was attached to the 5'-terminal phosphate of the oligodeoxyribonucleotide pCCCTCTTTCTT. The oligonucleotide derivative prepared was used for modification of the 365-nucleotide-long DNA fragment. It was found that modification of the fragment proceeds in a sequence-specific way at 3 guanosine residues within the sequence complementary to the oligonucleotide reagent.
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