These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Are there adverse effects of periconceptional spermicide use?
    Author: Mills JL, Reed GF, Nugent RP, Harley EE, Berendes HW.
    Journal: Fertil Steril; 1985 Mar; 43(3):442-6. PubMed ID: 3979584.
    Abstract:
    Recent studies have suggested that spermicide exposure around conception may cause congenital malformations, reduced birth weight, or spontaneous abortion. This large, prospective study examined the risk for multiple malformation, patterns of malformations, low birth weight, preterm delivery, and spontaneous abortion in infants whose mothers used spermicides only before or after their last menstrual period, compared with a control group using other contraceptive methods. The multiple malformation rates in women using spermicides only before or after their last menstrual period were 3.8 and 4.8 per thousand, respectively. For the control groups, the corresponding rates were 5.4 and 6.4 (not significant). No pattern of malformations was found in spermicide-exposed infants. The risk of preterm delivery, the risk for producing a low-birth-weight (less than 2500 gm) infant, and the risk of spontaneous abortion were no higher in women exposed to spermicides than in women using other methods of contraception. This study finds no evidence that spermicide exposure around the time of conception is dangerous to the fetus. Recent studies have suggested that spermicide exposure around conception may cause congenital malformations, reduced birthweight, or spontaneous abortion. This large, prospective study examined the risk for multiple malformations, patterns of malformations, low birthweight, preterm delivery, and spontaneous abortion in infants whose mothers used spermicides only before or after their last menstrual period (LMP), compared with a control group using other contraceptive methods. The multiple malformation rates in women using spermicides only before or after their LMP were 3.8 and 4.8/1000, respectively. For the control groups, the corresponding rates were 5.4 and 6.4 (not significant). No pattern of malformations was found in spermicide-exposed infants. The risk of preterm delivery, the risk for producing a low birthweight (2500 gm) infant, and the risk of spontaneous abortion were no higher in women exposed to spermicides than in women using other methods of contraception. This study finds no evidence that spermicide exposure around the time of conception is dangerous to the fetus.
    [Abstract] [Full Text] [Related] [New Search]