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  • Title: Absolute configuration of 3-hydroxyadipic acid in human urine.
    Author: Svendsen JS, Whist JE, Sydnes LK.
    Journal: J Chromatogr; 1985 Jan 11; 337(1):9-19. PubMed ID: 3980660.
    Abstract:
    A method involving derivatization and combined gas chromatography--mass spectrometry has been developed to separate the enantiomers of 3-hydroxyadipic acid. By combining this method with asymmetric synthesis of the same acid, it has been shown that 3-hydroxyadipic acid excreted in urine consists of at least 95% of the L-enantiomer. This finding supports the hypothesis that dicarboxylic acids are degraded by ordinary beta-oxidation, and indicates that adipic acid may be converted into succinic acid.
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